KinTek Explorer Software

KinTek Explorer is scientific software for modeling, simulating, and fitting chemical reaction kinetics using numerical integration and nonlinear least-squares regression. KinTek Explorer is used by the pharmaceutical industry for drug discovery and optimization, and by universities as a teaching aid and research tool. We are available on Windows and OS X. We offer two version free demo version and professional version. 

We’re here to help: send us your data and proposed model, and we’ll model your experiment and provide you with a file you can use to fully explore and fit your data using the free demo version.

Research Institutions That Use KinTek Explorer


Key Features

  • Model arbitrarily complex reaction mechanisms using simple text descriptions: E + S = ES = EP. From this description, differential equations are generated allowing the mechanism to be numerically modeled and fit to your data without simplifying assumptions. 

  • Define a variety of experiments including kinetic transients, steady-state kinetics, equilibrium titrations, fixed time point assays, and time-resolved spectra, and fit them all, simultaneously, to this single unifying model. Conduct and fit data from series experiments based on varying concentration, temperature, or voltage. 

  • Dynamic interactive simulation: “drag” rate constants or other model parameters with the mouse, and watch the output curves change in real time, allowing an intuitive understanding of the kinetics involved, and interactive exploration of initial parameters for data fitting.

  • Fully-featured data-fitting with provisions for linked reaction rates, boundaries on rates and starting concentrations, and contour analysis of correlation among fitted parameters.  

  • Using the SpectraFit™ add-on, analyze multi-wavelength time-evolved spectra, by itself or in combination with other types of experiments. 

  • Export your results to text files for further work in other applications, or directly create publication-quality graphs as encapsulated-postscript (EPS) or PNG files.


No Simplifying Approximations are Needed 

The field of enzyme kinetics evolved before computers were available. In the early days, it was out of necessity that kinetic data was treated with transforms such as, Lineweaver-Burke plots, and an assortment of other derivations. Now, powerful computers are available that can perform billions of calculations per second. A fundamental problem with the enzyme kinetic field of today is that antiquated methods are still in use, in spite of the fact that they have inherent problems, introducing error through the overemphasis of certain parts of the data and underemphasis of other parts of the data. 

The KinTek Explorer bypasses all the inherent problems of these transforms by directly treating your data in the context of your model. There are no simplifying assumptions needed. The errors are treated at face value.

Step out of the pre-computer age and give your data the treatment it deserves!

Global Fit: The figure shows an example of a good global fit obtained for experiments with widely varying signals intensities. Experiment 1 rapid chemical quench-flow data. Experiment 2 represents stopped-flow fluorescence data. The two experiments are fit simultaneously so that the data shows the correlation between chemistry and fluorescence signals. These data are provided in the example file HIVRT_fluor_qf.mec, from a paper by Kellinger and Johnson.

Global Fit: The figure shows an example of a good global fit obtained for experiments with widely varying signals intensities. Experiment 1 rapid chemical quench-flow data. Experiment 2 represents stopped-flow fluorescence data. The two experiments are fit simultaneously so that the data shows the correlation between chemistry and fluorescence signals. These data are provided in the example file HIVRT_fluor_qf.mec, from a paper by Kellinger and Johnson.


Papers Published Describing KinTek Explorer